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DLin-KC2-DMA (CAS No 1190197-97-7) is a lipid-based nanoparticle formulation commonly used in the field of biomedical research particularly in the delivery of nucleic acids for gene therapy and RNA interference Originating from advancements in lipid nanoparticle technology it functions by encapsulating therapeutic nucleic acids facilitating their cellular uptake and endosomal escape This enables effective delivery into target cells enhancing gene silencing or expression DLin-KC2-DMA exhibits potent activity in vitro typically in the nanomolar to low micromolar range allowing it to be a versatile tool in drug development and screening Its applications extend to various cell models including primary and immortalized cell lines as well as in vivo animal studies where it aids in the evaluation of gene delivery efficacy and safety Experimental concentrations typically depend on the specific research design to ensure optimal results within each study s context
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DODMA is a cationic lipid used in the preparation of lipid nanoparticles for drug delivery. Its pH-titratable head group remains neutral at physiological pH for systemic circulation, but protonates in the acidic environment of endosomes, facilitating fusion with the endosome membrane and aiding nucleic acid release.
Cationic lipid
Can be used to prepare lipid nanoparticles
Can be used for drug delivery
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18:0 mPEG2000 PE sodium is a PEGylated phosphoethanolamine lipid used as a PEG-lipid component in lipid nanoparticles, micelles, and other drug-delivery formulations to confer steric stabilization and modify circulation properties. Supplied as the sodium salt in a solid form, it is intended for research use in formulation and delivery studies.
Provides steric stabilization to nanoparticle surfaces.
Suitable for lipid nanoparticle and micelle formulations.
Sodium salt form for aqueous compatibility.
High purity suitable for research applications.
White to off-white solid, easy to handle and store.
Soluble in DMSO with warming and sonication.
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An analog of the PKC-activating second messengers collectively called DAG; equipotent to 1,2-dioctanoyl-sn-glycerol in induction of the acrosome reaction in human sperm
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